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KMID : 0378119870140010337
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Chungnam Medical Journal
1987 Volume.14 No. 1 p.337 ~ p.347
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An Experimental Study on Renal Artery Embolization With Sotradecol^(®) and Tetracycline
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Abstract
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Transcatheter embolization of renal artery using Gelfoam^(®) soaked in Sotradecol^(®)(sodium tetradecyl sulfate) and Tetracycline solution in rabbits was performed to evaluate the effect of intra-arterial inject ion.
Selective renal arteriography was done at 15 minutes, 1 week and 4 weeks after embolization. The rabbits were subsequently sacrificed and histopathologic examination performed.
The result were as follows:
1. Initial segmental occlusion was sustained in 11 of 16 cases that performed follow-up angiography. Recanalized vessels showed irregular narrowing ana marked decrease in number in 2 of 5 cases and progressive occlusion of segmental and proximal renal artery in 3 of 5 cases.
2. The infarcted kidneys were swollen ana enlarged at 1 week. There were resulted in shrinkage of infarcted kidney and compansatory hypertrophy of opposite kidney depending on intitial extent of infarcted area at 4 weeks.
3. After embolization, minute collateral vessels were developed in 10 of 16 cases without remarkable nephrogram in infarcted area.
4. The effect of Tetracycline seemed to be similar to that of Sotradecol in producing arterial occlusion. 5% Tetracycline was more injurious than 2.5% concentration in occlusion of renal artery.
5. Abscess formation within infarcted kidney was occurred in two casts using Sotradecol but not occurred in cases using Tetracycline.
6. Sotradecol and Tetracycline were the effective agents of producing persistent renal infarction with peripheral as well as central occlusion.
It was consirdered that intra-arterial injection of Tetracycline was the available mean of producing persistent renal artery embolization.
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